منابع مشابه
A Ror recruit to mammary gland development
All signaling pathways have their complexities , but Wnt signaling may be more complex than most. There are 19 different Wnt ligands in mammals that bind to multiple types of receptors, some of which activate a canonical pathway that stabilizes the tran-scriptional coactivator -catenin, and some of which signal via noncanonical, -catenin– independent pathways. Roarty et al. begin to unpick th...
متن کاملMammary gland development and cancer.
The mammary gland is a complex organ that begins development early in gestation and constantly changes in size, shape and function from the time of puberty to menopause. The earliest stages of embryogenesis appear to be independent of steroid hormones, whereas after the 15th week breast structure is largely influenced by a variety of hormones. In most females, further breast development begins ...
متن کاملChanges in lipogenesis during mammary-gland development.
The mammary gland is an excellent system with which to study differentiation. During pregnancy, differentiation can be monitored by measuring the biochemical changes that lead to the unique ability of the lobulo-alveolar tissue to synthesize milk components such as milk fat. Unlike most mammalian tissues, the lactating mammary gland of many species synthesizes medium-chain (C, : o-Clz : o ) fat...
متن کاملPPAR signaling exacerbates mammary gland tumor development
Breast cancer cell lines that express the nuclear peroxisome proliferator-activated receptor (PPAR ) can be prompted to undergo growth arrest and differentiation when treated with synthetic PPAR ligands. To evaluate the therapeutic potential of increased PPAR signaling in vivo, we generated transgenic mice that express a constitutively active form of PPAR in mammary gland. These mice are indist...
متن کاملMammary Gland Development, Reproductive History, and Breast Cancer Risk a
The observation that normal pathways of differentiation and development are invariably altered during the process of carcinogenesis implies an intrinsic relationship between these processes. This relationship is particularly evident in the breast, as exemplified by the existence of endocrine risk factors for breast cancer that are related to the timing of normal developmental events. Understand...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2015
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.2083if